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| Content Provider | PubMed Central |
|---|---|
| Author | Loon, A. M. Van Van, Der Logt J. T. Heessen, F. W. Heeren, M. C. Zoll, J. |
| Abstract | Antibody-capture enzyme-linked immunosorbent assays (AC-ELISA) which use enzyme-labelled antigen were developed for detection of varicella-zoster virus-(VZV) specific IgM, IgA and IgG antibody in patients with varicella or herpes zoster and in sera from healthy individuals. All 18 patients with varicella developed a VZV-IgM and a VZV-IgG response, 17 also a VZV-IgA response. In contrast, all 19 patients with herpes zoster were shown to be positive for VZV-IgA whereas only 13 of these reacted positively for VZV-IgM. A VZV-IgM response was detected in only two sera from 100 healthy individuals and an IgA response in only one. The presence of virus-specific IgA and IgG in the cerebrospinal fluid as determined by AC-ELISA was a useful indicator of VZV infection of the central nervous system. By AC-ELISA, VZV-IgG was detected predominantly in sera from patients with acute or recent VZV infection. Only 14 sera from 100 healthy individuals were positive for VZV-IgG by AC-ELISA, whereas all were positive by an indirect ELISA. These results indicate that AC-ELISA's may be useful assays for determination for acute or recurrent VZV infection, but are not suitable for determination of past infection with this virus. |
| Starting Page | 165 |
| File Format | |
| ISSN | 09502688 |
| Journal | Epidemiology and Infection |
| Issue Number | 1 |
| Volume Number | 108 |
| Language | English |
| Publisher | Cambridge University Press |
| Publisher Date | 1992-02-01 |
| Access Restriction | Open |
| Rights Holder | Cambridge University Press |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Epidemiology |
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