NDLI: V1a- and V2-type vasopressin receptors mediate vasopressin-induced Ca2+ responses in isolated rat supraoptic neurones

Content Provider	PubMed Central
Author	Laurent, Gouzènes Sabatier, Nancy Richard, Philippe Moos, Françoise C. Govindan, Dayanithi
Copyright Year	1999
Abstract	The pharmacological profile of receptors activated by vasopressin (AVP) in freshly dissociated supraoptic magnocellular neurones was investigated using specific V1a- and V2-type AVP receptor agonists and antagonists. In 97 % of AVP-responding neurones (1–3000 nm) V1a or V2 receptor type agonists (F-180 and dDAVP, respectively) elicited dose-dependent [Ca2+]i transients that were suppressed by removal of external Ca2+. The [Ca2+]i response induced by 1 μm F-180 or dDAVP was selectively blocked by 10 nm of V1a and V2 antagonists (SR 49059 and SR 121463A, respectively). The response to V1a agonist was maintained in the presence of the V2 antagonist, and the V2 agonist-induced response persisted in the presence of the V1a antagonist. The [Ca2+]i response induced by 1 μm AVP was partially (61 %) blocked by 10 nm SR 121463A. This blockade was increased by a further 31 % with the addition of 10 nm SR 49059. Similarly, the AVP-induced response was partially (47 %) decreased by SR 49059, and a further inhibition of 33 % was achieved in the presence of SR 121463A. We demonstrate that AVP acts on the magnocellular neurones via two distinct types of AVP receptors that exhibit the pharmacological profiles of V1a and V2 types. However, since V2 receptor mRNA is not expressed in the supraoptic nucleus (SON), and since V1b receptor transcripts are observed in the SON, we propose that the V2 receptor agonist and antagonist act on a ‘V2-like’ receptor or a new type of AVP receptor that remains to be elucidated. The possibility that V2 ligands act on the V1b receptor cannot be excluded.
Related Links	http://dx.doi.org/10.1111/j.1469-7793.1999.0771s.x
Ending Page	779
Page Count	9
Starting Page	771
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 3
Volume Number	517
Language	English
Publisher	Blackwell Science Inc
Publisher Date	1999-06-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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