NDLI: The half-life of the T-cell receptor/peptide–major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge

Content Provider	PubMed Central
Author	Carreño, Leandro J. Bueno, Susan M. Bull, Paulina Nathenson, Stanley G. Kalergis, Alexis M.
Copyright Year	2007
Abstract	T-cell activation results from engagement of the T-cell receptor (TCR) by cognate peptide–major histocompatibility complex (pMHC) complexes on the surface of antigen-presenting cells (APC). Previous studies have provided evidence supporting the notion that the half-life of the TCR/pMHC interaction and the density of pMHC on the APC are two parameters that can influence T-cell activation. However, whether the half-life of the TCR/pMHC interaction can modulate T-cell activation in response to a pathogen challenge remains unknown. To approach this question, we generated strains of bacteria expressing variants of the ovalbumin (OVA) antigen, carrying point mutations in the SIINFEKL sequence. When bound to H-2Kb, this peptide is the cognate ligand for the OT-I TCR. Variants of the H-2Kb/SIINFEKL bind to the OT-I TCR with distinct half-lives. Here we show that dendritic cells (DCs) infected with bacteria expressing OVA variants were incapable of activating OT-I T cells when the half-life of the TCR/H-2Kb/OVA interaction was excessively short. Consistent with these data, T-cell activation was only observed in mice infected with bacteria expressing OVA variants that bound to OT-I with a half-life above a certain threshold. Considered together, our data suggest that the half-life of TCR/pMHC interaction can significantly modulate T-cell activation in vivo, as well as influence recognition of antigens expressed by bacteria. These observations underscore the importance of the TCR/pMHC half-life on the clearance of pathogens.
Related Links	http://dx.doi.org/10.1111/j.1365-2567.2007.02561.x
Ending Page	237
Page Count	11
Starting Page	227
File Format	PDF
ISSN	00192805
e-ISSN	13652567
Journal	Immunology
Issue Number	2
Volume Number	121
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2007-06-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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