NDLI: CD4+ CD5+ regulatory T cells render naive CD4+ CD25

Content Provider	PubMed Central
Author	Qiao, Miao Thornton, Angela M. Shevach, Ethan M.
Copyright Year	2007
Abstract	CD4+ CD25+ Foxp3+ naturally occurring regulatory T cells (nTreg) are potent inhibitors of almost all immune responses. However, it is unclear how this minor population of cells is capable of exerting its powerful suppressor effects. To determine whether nTreg mediate part of their suppressor function by rendering naive T cells anergic or by converting them to the suppressor phenotype, we cocultured mouse nTreg with naive CD4+ CD25– T cells from T-cell receptor (TCR) transgenic mice on a RAG deficient (RAG–/–) background in the presence of anti-CD3 and interleukin-4 (IL-4) to promote cell viability. Two distinct responder cell populations could be recovered from the cocultures. One population remained undivided in the coculture and was non-responsive to restimulation with anti-CD3 or exogenous IL-2, and could not up-regulate IL-2 mRNA or CD25 expression upon TCR restimulation. Those responder cells that had divided in the coculture were anergic to restimulation with anti-CD3 but responded to restimulation with IL-2. The undivided population was capable of suppressing the response of fresh CD4+ CD25– T cells and CD8+ T cells, while the divided population was only marginally suppressive. Although cell contact between the induced regulatory T cell (iTreg) and the responders was required for suppression to be observed, anti-transforming growth factor-β partially abrogated their suppressive function. The iTreg did not express Foxp3. Therefore nTreg are not only able to suppress immune responses by inhibiting cytokine production by CD4+ CD25– responder cells, but also appear to modulate the responder cells to render them both anergic and suppressive.
Related Links	http://dx.doi.org/10.1111/j.1365-2567.2007.02544.x
Ending Page	455
Page Count	9
Starting Page	447
File Format	PDF
ISSN	00192805
e-ISSN	13652567
Journal	Immunology
Issue Number	4
Volume Number	120
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2007-04-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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