NDLI: Excursion is important in regulating sarcomere number in the growing rabbit tibialis anterior

Content Provider	PubMed Central
Author	Koh, Timothy J. Herzog, Walter
Copyright Year	1998
Abstract	The mechanical signal(s) that may be important in regulating the number of sarcomeres in series in skeletal muscle fibres or fascicles (sarcomere number) remain(s) speculative, in part because the in vivo mechanical environment of muscle has not yet been defined during sarcomere number perturbations. In the present study, measurements of the in vivo mechanical environment were used to test the hypothesis that increasing muscle excursion results in increased serial sarcomere addition in growing animals. The tibialis anterior (TA) was released from its retinacular restraint at the ankle joint to increase muscle excursion in 4-week-old female New Zealand White rabbits. Twelve weeks post release, muscle excursion and sarcomere number were significantly increased for released TAs compared with control TAs. General cage activity over a 24 h period and in vivo ankle joint kinematics of the experimental leg during hopping on a treadmill were not significantly different between control and release groups, suggesting that altered animal and joint activity patterns were not responsible for the increased serial sarcomere addition associated with TA release. In vivo TA forces during hopping and during a large force-producing foot-flicking motion were significantly decreased in released TAs compared with control TAs. Chronically decreased force production may have been involved in the decreased longitudinal tendon growth observed for the released TA compared with the control TA, which, in turn, may have stimulated the increase in serial sarcomere addition. However, increasing force production of the released TA by partial ablation of the extensor digitorum longus did not inhibit the increase in serial sarcomere addition. The results of this study support the hypothesis that increasing excursion results in increased serial sarcomere addition in growing animals and, when combined with the results of previous studies indicating that decreasing excursion results in decreased serial sarcomere addition, support the working hypothesis that excursion is important in regulating sarcomere number in growing animals.
Related Links	http://dx.doi.org/10.1111/j.1469-7793.1998.267br.x
Ending Page	280
Page Count	14
Starting Page	267
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	508
Language	English
Publisher	Blackwell Science Inc
Publisher Date	1998-04-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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