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| Content Provider | PubMed Central |
|---|---|
| Author | Febo, Marcelo Ferris, Craig F. |
| Abstract | Pups are a highly rewarding stimulus for early postpartum rats. Our previous work supports this notion by showing that suckling activates the mesocorticolimbic system in mothers. In the present study, we tested whether development of behavioral sensitization to cocaine before pregnancy affects the neural response to pups during the early postpartum days (PD). Virgin rats were repeatedly administered cocaine for 14 days (15 mg kg-1) and withdrawn from treatment during breeding and pregnancy. The neural response to suckling was measured at PD 4 to 8 using blood-oxygen-level-dependent (BOLD) MRI or microdialysis. Our results show that BOLD activation in the medial prefrontal cortex (PFC), septum and auditory cortex was curtailed in cocaine-sensitized dams. No differences between cocaine sensitized and saline control dams were observed in the nucleus accumbens, olfactory structures, or in 48 additional major brain regions that were analyzed. Baseline, but not pup-stimulated, dopamine (DA) levels in the medial PFC was lower in cocaine-sensitized dams than in controls. When tested for maternal behaviors, cocaine sensitized dams showed significantly faster retrieval of pups without changes in other maternal behaviors such as grouping, crouching and defending the nest. Taken together, the present findings suggest that maternal motivation to retrieve pups was enhanced by repeated cocaine exposure and withdrawal, a result reminiscent of ‘cross sensitization’ between the drug and a natural reward. Changes in retrieval behavior in cocaine-sensitized mothers might be associated with a hypo-responsive medial PFC. |
| Related Links | http://dx.doi.org/10.1016/j.neuroscience.2007.05.026 |
| Ending Page | 412 |
| Page Count | 13 |
| Starting Page | 400 |
| File Format | |
| ISSN | 03064522 |
| Journal | Neuroscience |
| Issue Number | 2 |
| Volume Number | 148 |
| Language | English |
| Publisher Date | 2007-08-01 |
| Access Restriction | Open |
| Subject Keyword | Neuroscience(all) Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience |
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