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| Content Provider | PubMed Central |
|---|---|
| Author | Muraro, Paolo A. Douek, Daniel C. Packer, Amy Chung, Katherine Guenaga, Francisco J. Riccardo, Cassiani-ingoni Campbell, Catherine Memon, Sarfraz Nagle, James W. Hakim, Frances T. Gress, Ronald E. Mcfarland, Henry F. Burt, Richard K. Martin, Roland |
| Abstract | Clinical trials have indicated that autologous hematopoietic stem cell transplantation (HSCT) can persistently suppress inflammatory disease activity in a subset of patients with severe multiple sclerosis (MS), but the mechanism has remained unclear. To understand whether the beneficial effects on the course of disease are mediated by lympho-depletive effects alone or are sustained by a regeneration of the immune repertoire, we examined the long-term immune reconstitution in patients with MS who received HSCT. After numeric recovery of leukocytes, at 2-yr follow-up there was on average a doubling of the frequency of naive CD4+ T cells at the expense of memory T cells. Phenotypic and T cell receptor excision circle (TREC) analysis confirmed a recent thymic origin of the expanded naive T cell subset. Analysis of the T cell receptor repertoire showed the reconstitution of an overall broader clonal diversity and an extensive renewal of clonal specificities compared with pretherapy. These data are the first to demonstrate that long-term suppression of inflammatory activity in MS patients who received HSCT does not depend on persisting lymphopenia and is associated with profound qualitative immunological changes that demonstrate a de novo regeneration of the T cell compartment. |
| Related Links | http://dx.doi.org/10.1084/jem.20041679 |
| Ending Page | 816 |
| Page Count | 12 |
| Starting Page | 805 |
| File Format | |
| ISSN | 00221007 |
| e-ISSN | 15409538 |
| Journal | The Journal of Experimental Medicine |
| Issue Number | 5 |
| Volume Number | 201 |
| Language | English |
| Publisher | The Rockefeller University Press |
| Publisher Date | 2005-03-07 |
| Access Restriction | Open |
| Rights Holder | The Rockefeller University Press |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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