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| Content Provider | PubMed Central |
|---|---|
| Author | Grouard, Géraldine Rissoan, Marie-clotilde Filgueira, Luis Durand, Isabelle Jacques, Banchereau Liu, Yong-jun |
| Copyright Year | 1997 |
| Abstract | A subset of CD4+CD11c−CD3− blood cells was recently shown to develop into dendritic cells when cultured with monocyte conditioned medium. Here, we demonstrate that CD4+ CD11c−CD3− cells, isolated from tonsils, correspond to the so-called plasmacytoid T cells, an obscure cell type that has long been observed by pathologists within secondary lymphoid tissues. They express CD45RA, but not markers specific for known lymphoid- or myeloid-derived cell types. They undergo rapid apoptosis in culture, unless rescued by IL-3. Further addition of CD40-ligand results in their differentiation into dendritic cells that express low levels of myeloid antigens CD13 and CD33. |
| Starting Page | 1101 |
| File Format | |
| ISSN | 15409538 |
| e-ISSN | 15409538 |
| Journal | The Journal of Experimental Medicine |
| Issue Number | 6 |
| Volume Number | 185 |
| Language | English |
| Publisher | The Rockefeller University Press |
| Publisher Date | 1997-03-17 |
| Access Restriction | Open |
| Rights Holder | The Rockefeller University Press |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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