NDLI: THE EFFECT OF X-RADIATION ON THE GLUTATHIONE METABOLISM OF INTACT ERYTHROCYTES IN VITRO

Content Provider	PubMed Central
Author	Klebanoff, S. J.
Abstract	The x-irradiation of intact washed erythrocytes results in an inhibition of the glyoxalase activity of the cells chiefly as a result of a decrease in the reduced glutathione level. The percentage inhibition is markedly increased by an increase in the dilution of the cells in physiological saline suggesting that the effect of radiation is indirect, via the production in the aqueous medium of free radicals, H2O2, etc. This is supported by the decrease in the inhibition produced by lowering the oxygen tension or by the addition of catalase. The inhibition of glyoxalase activity is also decreased by the addition of methylglyoxal, plasma, adenosine, inosine, glucose, and a number of other sugars to the erythrocyte suspension prior to radiation. Furthermore, some reactivation of the glyoxalase system results from the addition of plasma, glucose, adenosine, and inosine following radiation. These results are discussed in relation to the role of SH compounds, particularly glutathione, in the toxicity of ionizing radiations.
Starting Page	725
File Format	PDF
ISSN	15407748
e-ISSN	15407748
Journal	The Journal of General Physiology
Issue Number	4
Volume Number	41
Language	English
Publisher	The Rockefeller University Press
Publisher Date	1958-03-20
Access Restriction	Open
Rights Holder	The Rockefeller University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology

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THE EFFECT OF X-RADIATION ON THE GLUTATHIONE METABOLISM OF INTACT ERYTHROCYTES IN VITRO