NDLI: Dorsal hippocampal N-methyl-d-aspartate receptors underlie spatial working memory performance during non-matching to place testing on the T-maze

Content Provider	PubMed Central
Author	Mchugh, Stephen B. Niewoehner, Burkhard Rawlins, J. N. P. Bannerman, David M.
Copyright Year	2007
Abstract	Previous lesion studies have suggested a functional dissociation along the septotemporal axis of the hippocampus. Whereas the dorsal hippocampus has been implicated in spatial memory processes, the ventral hippocampus may play a role in anxiety. However, these lesion studies are potentially confounded by demyelination of fibres passing through the lesion site, and the possibility of secondary, downstream changes in associated brain structures as a consequence of their chronic denervation following the lesion. In the present study, we have used the microinfusion of muscimol to temporarily inactivate either the dorsal or ventral hippocampus in order to re-examine the contribution of the hippocampal sub-regions to spatial memory. Microinfusion studies spare fibres of passage and offer fewer opportunities for compensatory changes because the effects are transient and short-lasting. Rats were infused prior to spatial working memory testing on a non-matching to place T-maze alternation task. Spatial working memory was impaired by dorsal but not ventral hippocampal inactivation. In a second experiment, infusion of the NMDAR antagonist, D-AP5, into dorsal hippocampus also impaired spatial working memory performance, suggesting that NMDAR function within the dorsal hippocampus makes an essential contribution to this aspect of hippocampal information processing.
Related Links	http://dx.doi.org/10.1016/j.bbr.2007.07.021
Ending Page	47
Page Count	7
Starting Page	41
File Format	PDF
ISSN	01664328
e-ISSN	18727549
Journal	Behavioural Brain Research
Issue Number	1
Volume Number	186
Language	English
Publisher	Elsevier/North-Holland Biomedical Press
Publisher Date	2008-01-01
Access Restriction	Open
Rights Holder	Elsevier/North-Holland Biomedical Press
Subject Keyword	Behavioral Neuroscience Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Behavioral Neuroscience

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