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| Content Provider | PubMed Central |
|---|---|
| Author | Gladden, John M. Farboud, Behnom Meyer, Barbara J. |
| Abstract | In Caenorhabditis elegans, sex is determined by the opposing actions of X-signal elements (XSEs) and autosomal signal elements (ASEs), which communicate the ratio of X chromosomes to sets of autosomes (X:A signal). This study delves more deeply into the mechanism by which XSEs transmit X chromosome dose. We determined the relative contributions of individual XSEs to the X:A signal and showed the order of XSE strength to be sex-1 > sex-2 > fox-1 > ceh-39 ≥ region 1 XSE. sex-1 exerts a more potent influence on sex determination and dosage compensation than any other XSE by functioning in two separate capacities in the pathway: sex-1 acts upstream as an XSE to repress xol-1 and downstream as an activator of hermaphrodite development and dosage compensation. Furthermore, the process of dosage compensation affects expression of the very XSEs that control it; XSEs become fully dosage compensated once sex is determined. The X:A signal is then equivalent between XO and XX animals, causing sexual differentiation to be controlled by genes downstream of xol-1 in the sex-determination pathway. Prior to the onset of dosage compensation, the difference in XSE expression between XX and XO embryos appears to be greater than twofold, making X chromosome counting a robust process. |
| Related Links | http://dx.doi.org/10.1534/genetics.107.078071 |
| Ending Page | 1654 |
| Page Count | 16 |
| Starting Page | 1639 |
| File Format | |
| ISSN | 00166731 |
| Journal | Genetics |
| Issue Number | 3 |
| Volume Number | 177 |
| Language | English |
| Publisher | Genetics Society of America |
| Publisher Date | 2007-11-01 |
| Access Restriction | Open |
| Rights Holder | Genetics Society of America |
| Subject Keyword | Genetics Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics |
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