NDLI: Antiatherogenic effects of the antioxidant BO-653 in three different animal models

Content Provider	PubMed Central
Author	Cynshi, Osamu Kawabe, Yoshiki Suzuki, Tsukasa Takashima, Yoshiaki Kaise, Hiroshi Nakamura, Minako Ohba, Yasuhiro Kato, Yoshiaki Tamura, Kunio Hayasaka, Akira Higashida, Atsuko Sakaguchi, Hisashi Takeya, Motohiro Takahashi, Kiyoshi Inoue, Kenji Noguchi, Noriko Niki, Etsuo Kodama, Tatsuhiko
Copyright Year	1998
Abstract	Antioxidants have been proposed to have antiatherogenic potential by their inhibition of low density lipoprotein (LDL) oxidation. Here, we report an antioxidant, BO-653 (2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran), designed to exhibit antioxidative potency comparable to that of α-tocopherol, but yet possess a high degree of lipophilicity comparable to that of probucol. BO-653 exhibits a high affinity for LDL and is well distributed in aortic vessels in vivo. In atherosclerosis models of rabbits and mice, BO-653 has been shown to be able to suppress the formation of atherosclerotic lesions without untoward side effects. Specifically, there was no reduction of high density lipoprotein levels. This antioxidant provides additional evidence in support of the oxidized-LDL hypothesis, and itself is a promising candidate antioxidant for clinical use.
Starting Page	10123
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	95
Language	English
Publisher	The National Academy of Sciences
Publisher Date	1998-08-18
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Antiatherogenic effects of the antioxidant BO-653 in three different animal models.

Evaluation of Lipophilic Antioxidant Efficacy in Vivo by the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane

Antiatherogenic effects of vitamin E: the search for the Holy Grail

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

On the antiatherogenic effects of vitamin E: the search for the Holy Grail

Evaluation of Three Different Methods to Establish Animal Models of Acanthamoeba Keratitis

Evaluation of the Antioxidant Activity of Three Varieties of Honey from Different Botanical and Geographical Origins

Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein

Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages

Antiatherogenic effects of the antioxidant BO-653 in three different animal models

Similar Documents

Antiatherogenic effects of the antioxidant BO-653 in three different animal models.

Evaluation of Lipophilic Antioxidant Efficacy in Vivo by the Biomarkers Hydroxyoctadecadienoic Acid and Isoprostane

Antiatherogenic effects of vitamin E: the search for the Holy Grail

Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit.

On the antiatherogenic effects of vitamin E: the search for the Holy Grail

Evaluation of Three Different Methods to Establish Animal Models of Acanthamoeba Keratitis

Evaluation of the Antioxidant Activity of Three Varieties of Honey from Different Botanical and Geographical Origins

Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein

Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages

Antiatherogenic effects of the antioxidant BO-653 in three different animal models