NDLI: CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40

Content Provider	PubMed Central
Author	Macleod, Megan Kwakkenbos, Mark J. Crawford, Alison Brown, Sheila Stockinger, Brigitta Schepers, Koen Schumacher, Ton Gray, David
Abstract	Secondary T cell responses are enhanced because of an expansion in numbers of antigen-specific (memory) cells. Using major histocompatibility complex class II tetramers we have tracked peptide-specific endogenous (non–T cell receptor transgenic) CD4 memory T cells in normal and in costimulation-deficient mice. CD4 memory T cells were detectable after immunization for more than 200 days, although decay was apparent. Memory cells generated in CD40 knockout mice by immunization with peptide-pulsed wild-type dendritic cells survived in the absence of CD40 and proliferated when boosted with peptide (plus adjuvant) in a CD40-independent fashion. However, differentiation of the memory cells into cytokine-producing effector cells did not occur in the absence of CD40. The data indicate that memory cells can be generated without passing through the effector cell stage.
Related Links	http://dx.doi.org/10.1084/jem.20050711
Starting Page	897
File Format	PDF
ISSN	15409538
e-ISSN	15409538
Journal	The Journal of Experimental Medicine
Issue Number	4
Volume Number	203
Language	English
Publisher	The Rockefeller University Press
Publisher Date	2006-04-17
Access Restriction	Open
Rights Holder	The Rockefeller University Press
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40