NDLI: Cerebral blood flow and oxygenation in ovine fetus: responses to superimposed hypoxia at both low and high altitude

Content Provider	PubMed Central
Author	Pereyra, Peňa Jorge Tomimatsu, Takuji Hatran, Douglas P. Mcgill, Lisa L. Longo, Lawrence D.
Copyright Year	2007
Abstract	For the fetus, although the roles of arterial blood gases are recognized to be critical in the regulation of cerebral blood flow (CBF) and cerebral oxygenation, the relation of CBF, cortical tissue P O2 (t P O2 ), sagittal sinus P O2 , and related indices of cerebral oxygenation to arterial blood gases are not well defined. This is particularly true for that fetus subjected to long-term hypoxia (LTH). In an effort to elucidate these interrelations, we tested the hypothesis that in the fetus acclimatized to high altitude, cerebral oxygenation is not compromised relative to that at low altitude. By use of a laser Doppler flowmeter with a fluorescent O2 probe, in near-term fetal sheep at low altitude (n = 8) and those acclimatized to high altitude hypoxia (3801 m for 90 ± 5 days; n = 6), we measured laser Doppler CBF (LD-CBF), t P O2 , and related variables in response to 40 min superimposed hypoxia. At both altitudes, fetal LD-CBF, cerebral O2 delivery, t P O2 , and several other variables including sagittal sinus P O2 , correlated highly with arterial P O2 (P a,O2 ). In response to superimposed hypoxia (P a,O2 = 11 ± 1 Torr), LD-CBF was significantly blunted at high altitude, as compared with that at low altitude. In the two altitude groups fetal cerebral oxygenation was similar under both control conditions and with superimposed hypoxia, cortical t P O2 decreasing from 8 ± 1 and 6 ± 1 Torr, respectively, to 2 ± 1 Torr. Also, for these conditions sagittal sinus P O2 and [HbO2] values were similar. In response to superimposed hypoxia, cerebral metabolic rate for O2 decreased ∼50% in each group (P < 0.05). For both the fetus at low altitude and that acclimatized to high altitude LTH, we present the first dose–response data on the relation of LD-CBF, cortical t P O2 , and sagittal sinus blood gas values to P a,O2 . In addition, despite differences in several variables, the fetus at high altitude showed evidence of successful acclimatization, supporting the hypothesis that such fetuses demonstrate no compromise in cerebral oxygenation.
Related Links	http://dx.doi.org/10.1113/jphysiol.2006.119925
Ending Page	370
Page Count	12
Starting Page	359
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	578
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2007-01-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

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