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| Content Provider | PubMed Central |
|---|---|
| Author | Stoops, William W. Vansickel, Andrea R. Lile, Joshua A. Rush, Craig R. |
| Abstract | Recent clinical research indicates that d-amphetamine is effective in treating cocaine and methamphetamine dependence. There is concern, however, with the use of d-amphetamine as a pharmacotherapy because acute administration of d-amphetamine decreases inhibition in cocaine-using individuals and may increase drug-taking behavior. The purpose of the present experiment was to determine whether acute d-amphetamine pretreatment would alter the reinforcing, subject-rated, and cardiovascular effects of d-amphetamine. To this end, 7 human volunteers first sampled doses of oral d-amphetamine (0, 8, and 16 mg). These doses engender moderate drug taking and were selected to avoid a ceiling or floor effect. Volunteers were then allowed to self-administer these sampled doses using a modified-progressive ratio procedure in two sessions in which they received pretreatments with either 0 or 15 mg oral d-amphetamine 2 hours prior to completing the modified progressive-ratio procedure. d-Amphetamine produced prototypical stimulant-like effects (e.g., increased ratings of stimulated, elevated blood pressure) and maintained responding on the modified progressive-ratio schedule. Pretreatment with 15 mg oral d-amphetamine also produced prototypical stimulant-like effects, but failed to alter break points for d-amphetamine on the modified progressive-ratio procedure relative to placebo pretreatment. These results indicate that acute d-amphetamine pretreatment does not increase stimulant self-administration. |
| Related Links | http://dx.doi.org/10.1016/j.pbb.2007.03.016 |
| Ending Page | 29 |
| Page Count | 10 |
| Starting Page | 20 |
| File Format | |
| ISSN | 00913057 |
| Journal | Pharmacology, biochemistry, and behavior |
| Issue Number | 1 |
| Volume Number | 87 |
| Language | English |
| Publisher Date | 2007-05-01 |
| Access Restriction | Open |
| Subject Keyword | Toxicology Clinical Biochemistry Biochemistry Biological Psychiatry Behavioral Neuroscience Pharmacology Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biological Psychiatry Behavioral Neuroscience Biochemistry Clinical Biochemistry Toxicology Pharmacology |
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