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| Content Provider | PubMed Central |
|---|---|
| Author | Gácser, Attila Stehr, Frank Kröger, Cathrin László, Kredics Schäfer, Wilhelm Nosanchuk, Joshua D. |
| Copyright Year | 2007 |
| Abstract | The production of lipases can affect microbial fitness and virulence. We examined the role of the lipase 8 (LIP8) gene in the virulence of Candida albicans by constructing Δlip8 strains by the URA-blaster disruption method. Reverse transcription-PCR experiments demonstrated the absence of LIP8 expression in the homozygous knockout mutants. Reconstituted strains and overexpression mutants were generated by introducing a LIP8 open reading frame under control of a constitutive actin promoter. Knockout mutants produced more mycelium, particularly at higher temperatures and pH ≥7. Diminished LIP8 expression resulted in reduced growth in lipid-containing media. Mutants deficient in the LIP8 gene were significantly less virulent in a murine intravenous infection model. The results clearly indicate that Lip8p is an important virulence factor of C. albicans. |
| Related Links | http://dx.doi.org/10.1128/iai.00372-07 |
| Ending Page | 4718 |
| Page Count | 9 |
| Starting Page | 4710 |
| File Format | |
| ISSN | 00199567 |
| e-ISSN | 10985522 |
| Journal | Infection and Immunity |
| Issue Number | 10 |
| Volume Number | 75 |
| Language | English |
| Publisher | American Society for Microbiology |
| Publisher Date | 2007-10-01 |
| Access Restriction | Open |
| Rights Holder | American Society for Microbiology |
| Subject Keyword | Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology Immunology Microbiology |
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