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| Content Provider | PubMed Central |
|---|---|
| Author | Jacobson, Eric M. Tomer, Yaron |
| Abstract | Autoimmune thyroid diseases (AITD) are common autoimmune diseases affecting up to 5% of the general population. Thyroid-directed autoimmunity is manifested in two classical autoimmune conditions, Hashimoto's thyroiditis, resulting in hypothyroidism and Graves' disease resulting in hyperthyroidism. Autoimmune thyroid diseases arise due to an interplay between environmental and genetic factors. In the past decade significant progress has been make in our understanding of the genetic contribution to the etiology of AITD. Indeed, several AITD susceptibility genes have been identified. Some of these susceptibility genes are specific to either Graves' disease or Hashimoto's thyroiditis, while others confer susceptibility to both conditions. Both immunoregulatory genes and thyroid specific genes contribute to the pathogenesis of AITD. The time is now ripe to examine the mechanistic basis for the contribution of genetic factors to etiology of disease. In this review, we will focus on the contribution of non-MHC II genes to the etiology of AITD. |
| Related Links | http://dx.doi.org/10.1016/j.jaut.2007.02.006 |
| Ending Page | 98 |
| Page Count | 14 |
| Starting Page | 85 |
| File Format | |
| ISSN | 08968411 |
| Journal | Journal of autoimmunity |
| Issue Number | 2-3 |
| Volume Number | 28 |
| Language | English |
| Publisher Date | 2007-03-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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