NDLI: Effect of partial portal vein ligation on immune glomerular deposits in Schistosoma mansoni-infected mice.

Content Provider	PubMed Central
Author	Marck, E. A. Van Deelder, A. M. Gigase, P. L.
Abstract	Portosystemic collateral circulation was induced in mice infected or not with Schistosoma mansoni by partial ligation of the portal vein. The effects on immune glomerular deposits were assessed and compared to findings in unoperated infected, sham-operated and normal animals. Mesangial immune deposits of IgM, IgA, IgG and C3 were found by immunofluorescence significantly more frequently in operated than in unoperated infected mice. Schistosomal antigen was demonstrated in 5 animals out of 38 infected ones, 4 of the 5 having been operated. The results suggest that portosystemic collateral circulation might be an important factor in the genesis of schistosomal glomerulopathy, perhaps by diversion of antigens or complexes from the Kupffer cells. The high percentage of glomerular immune deposits found in uninfected ligated animals (71-4%) suggests furthermore that non-specific immune factors possibly of intestinal origin could be involved.
Starting Page	412
File Format	PDF
ISSN	00071021
Journal	British journal of experimental pathology
Issue Number	4
Volume Number	58
Language	English
Publisher Date	1977-08-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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Effect of partial portal vein ligation on immune glomerular deposits in Schistosoma mansoni-infected mice.