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| Content Provider | PubMed Central |
|---|---|
| Author | Li, Bing Cramer, Daniel Wagner, Stephanie Hansen, Richard King, Chelsea Kakar, Shelly Ding, Chuanlin Yan, Jun |
| Abstract | The therapeutic benefits of fungal β-glucans have been demonstrated as immuno-stimulating agents. In this study, we aimed to explore the mechanisms used by yeast β-glucan-rich particles to activate murine resident macrophages for cytokine secretion. We demonstrated that resident macrophages were effectively activated by whole yeast β-glucan particles (WGPs), such as with the up-regulation of co-stimulatory molecules and the secretion of cytokines. The binding ability of WGPs and the levels of cytokine secretion in resident macrophages were significantly inhibited by soluble yeast β-glucan but not by blockade of zymosan glucan receptor dectin-1. In addition, WGP-stimulated cytokine secretion was partially dependent on the MyD-88 pathway but was not significantly affected in CR3-deficient (CR3−/−) mice. Furthermore, we showed that Syk kinase was recruited upon WGP stimulation and was required for the production of cytokines. Taken together, these observations suggest that β-glucan recognition is necessary but not sufficient to induce inflammatory response on resident macrophages. In addition, β-glucan particles may use differential mechanisms for cytokine secretion in resident macrophages that may modulate both innate and adaptive immunity. |
| Related Links | http://dx.doi.org/10.1016/j.clim.2007.05.002 |
| Ending Page | 181 |
| Page Count | 12 |
| Starting Page | 170 |
| File Format | |
| ISSN | 15216616 |
| Journal | Clinical immunology (Orlando, Fla.) |
| Issue Number | 2 |
| Volume Number | 124 |
| Language | English |
| Publisher Date | 2007-08-01 |
| Access Restriction | Open |
| Subject Keyword | Immunology Immunology and Allergy Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Immunology |
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