NDLI: TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation

Content Provider	PubMed Central
Author	Jacobi, Ulrike G. Akkers, Robert C. Pierson, Elisabeth S. Weeks, Daniel L. Dagle, John M. Veenstra, Gert Jan C.
Copyright Year	2007
Abstract	In addition to TATA-binding protein (TBP), a key factor for transcription initiation, the metazoan-specific TBP-like factor TLF/TRF2 and the vertebrate-specific factor TBP2/TRF3 are known to be required for transcription of specific subsets of genes. We have combined an antisense-knockdown approach with transcriptome profiling to determine the significance and biological role of TBP-independent transcription in early gastrula-stage Xenopus laevis embryos. Here, we report that, although each of the TBP family members is essential for embryonic development, relatively few genes depend on TBP in the embryo. Most of the transcripts that depend on TBP in the embryo are also expressed maternally and in adult stages, and show no functional specialization. In contrast, TLF is linked to preferential expression in embryos and shows functional specialization in catabolism. A requirement for TBP2 is linked to vertebrate-specific embryonic genes and ventral-specific expression. Therefore TBP paralogs are essential for the gene-regulatory repertoire that is directly linked to early embryogenesis.
Related Links	http://dx.doi.org/10.1038/sj.emboj.7601822
Ending Page	3909
Page Count	10
Starting Page	3900
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	17
Volume Number	26
Language	English
Publisher	Nature Publishing Group
Publisher Date	2007-09-05
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms

Vertebrate HoxB gene expression requires DNA replication

Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei.

Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation

Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides

SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment

Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation

Similar Documents

Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms

Vertebrate HoxB gene expression requires DNA replication

Position-dependent and promoter-specific regulation of gene expression in Trypanosoma brucei.

Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation

Specific targeting of insect and vertebrate telomeres with pyrrole and imidazole polyamides

SAGA binds TBP via its Spt8 subunit in competition with DNA: implications for TBP recruitment

Transcriptional repression and developmental functions of the atypical vertebrate GATA protein TRPS1

Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

TBP paralogs accommodate metazoan- and vertebrate-specific developmental gene regulation