NDLI: Recombinant simian varicella viruses induce immune responses to simian immunodeficiency virus (SIV) antigens in immunized vervet monkeys

Content Provider	PubMed Central
Author	Ou, Yang Traina-dorge, Vicki Davis, Kara A. Gray, Wayne L.
Abstract	The varicella-zoster virus (VZV) Oka vaccine offers potential as a recombinant vaccine against other pathogens. In this study, recombinant simian varicella viruses (rSVV) expressing simian immunodeficiency virus (SIV) envelope (env, gp130) and gag antigens were constructed. Expression of the SIV env and gag transcripts and antigens in rSVV infected Vero cells was confirmed. The rSVV-SIVenv and rSVV-SIVgag viruses replicated as efficiently as wild-type SVV in cell culture. The immunogenicity of rSVV-SIVenv and rSVV-SIVgag was investigated in immunized vervet monkeys. Humoral immune responses to the SIV gp130 and gag antigens were detected as early as four weeks after the initial immunization with higher antibody titers following a booster immunization. Cellular immune responses against the SIV gp130 antigen were detected by ELISPOT assay. The rSVV established latent infection in neural ganglia. A subsequent study will evaluate the ability of rSVV vaccines expressing SIV antigens to protect nonhuman primates against simian AIDS.
Related Links	http://dx.doi.org/10.1016/j.virol.2007.03.025
Ending Page	300
Page Count	10
Starting Page	291
File Format	PDF
ISSN	00426822
Journal	Virology
Issue Number	2
Volume Number	364
Language	English
Publisher Date	2007-08-01
Access Restriction	Open
Subject Keyword	Virology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology

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Recombinant simian varicella viruses induce immune responses to simian immunodeficiency virus (SIV) antigens in immunized vervet monkeys