NDLI: Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3

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Naturally acquired antibodies to polymorphic and conserved epitopes of Plasmodium falciparum merozoite surface protein 3

Content Provider	PubMed Central
Author	Osier, F. H. A. Polley, S. D. Mwangi, T. Lowe, B. Conway, D. J. Marsh, K.
Copyright Year	2007
Abstract	Many studies on the role of merozoite surface protein 3 (MSP3) in immunity against malaria have focused on a conserved section of MSP3. New evidence suggests that polymorphic sequences within MSP3 are under immune selection. We report a detailed analysis of naturally-acquired antibodies to allele-specific and conserved parts of MSP3 in a Kenyan cohort. Indirect and competition ELISA to heterologous recombinant MSP3 proteins were used for antibody assays, and parasites were genotyped for msp3 alleles. Antibody reactivity to allele-specific and conserved epitopes of MSP3 was heterogenous between individuals. Overall, the prevalence of allele-specific antibody reactivity was significantly higher (3D7-specific 54%, K1-specific 41%) than that to a recombinant protein representing a conserved portion of C-terminal MSP3 (24%, P < 0·01). The most abundant IgG subclass was IgG3, followed by IgG1. Allele-specific reactivity to the K1-type of MSP3 was associated with a lower risk of clinical malaria episodes during a 6-month follow-up in individuals who were parasitized at the start of the malaria transmission season (Relative risk 0·41 with 95% confidence interval 0·20–0·81, P = 0·011). The potential importance of allele-specific immunity to MSP3 should be considered in addition to immunity to conserved epitopes, in the development of an MSP3 malaria vaccine.
Related Links	http://dx.doi.org/10.1111/j.1365-3024.2007.00951.x
Ending Page	394
Page Count	8
Starting Page	387
File Format	PDF
ISSN	01419838
e-ISSN	13653024
Journal	Parasite Immunology
Issue Number	8
Volume Number	29
Language	English
Publisher	Blackwell Publishing Ltd
Publisher Date	2007-08-01
Access Restriction	Open
Rights Holder	Blackwell Publishing Ltd
Subject Keyword	Immunology Parasitology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Parasitology Immunology

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