NDLI: Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

Content Provider	PubMed Central
Author	Nassim, Dali-youcef Mataki, Chikage Coste, Agnès Nadia, Messaddeq Giroud, Sylvain Blanc, Stéphane Koehl, Christian Champy, Marie-france Chambon, Pierre Lluis, Fajas Metzger, Daniel Schoonjans, Kristina Johan, Auwerx
Copyright Year	2007
Abstract	The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb promotes a switch from white to brown adipocyte differentiation in vitro. We used the Cre-Lox system to specifically inactivate pRb in adult adipose tissue. Under a high-fat diet, pRb-deficient (pRbad−/−) mice failed to gain weight because of increased energy expenditure. This protection against weight gain was caused by the activation of mitochondrial activity in white and brown fat as evidenced by histologic, electron microscopic, and gene expression studies. Moreover, pRb−/− mouse embryonic fibroblasts displayed higher proliferation and apoptosis rates than pRb+/+ mouse embryonic fibroblasts, which could contribute to the altered white adipose tissue morphology. Taken together, our data support a direct role of pRb in adipocyte cell fate determination in vivo and suggest that pRb could serve as a potential therapeutic target to trigger mitochondrial activation in white adipose tissue and brown adipose tissue, favoring an increase in energy expenditure and subsequent weight loss.
Related Links	http://dx.doi.org/10.1073/pnas.0611568104
Ending Page	10708
Page Count	6
Starting Page	10703
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	104
Language	English
Publisher	National Academy of Sciences
Publisher Date	2007-06-19
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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