NDLI: Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

Content Provider	PubMed Central
Author	Freedman, Robert Coon, Hilary Marina, Myles-worsley Avi, Orr-urtreger Ann, Olincy Davis, Ashley Polymeropoulos, Mihael Holik, John Hopkins, Jan Hoff, Mark Rosenthal, Judy Waldo, Merilyne c. Fred, Reimherr Wender, Paul Yaw, Jeffrey Young, David a. Breese, Charles r. Adams, Catherine Patterson, David Adler, Lawrence e. Kruglyak, Leonid Leonard, Sherry Byerley, William
Copyright Year	1997
Abstract	Inheritance of a defect in a neuronal mechanism that regulates response to auditory stimuli was studied in nine families with multiple cases of schizophrenia. The defect, a decrease in the normal inhibition of the P50 auditory-evoked response to the second of paired stimuli, is associated with attentional disturbances in schizophrenia. Decreased P50 inhibition occurs not only in most schizophrenics, but also in many of their nonschizophrenic relatives, in a distribution consistent with inherited vulnerability for the illness. Neurobiological investigations in both humans and animal models indicated that decreased function of the α7-nicotinic cholinergic receptor could underlie the physiological defect. In the present study, a genome-wide linkage analysis, assuming autosomal dominant transmission, showed that the defect is linked [maximum logarithm of the odds (lod) score = 5.3 with zero recombination] to a dinucleotide polymorphism at chromosome 15q13-14, the site of the α7-nicotinic receptor. Despite many schizophrenics’ extremely heavy nicotine use, nicotinic receptors were not previously thought to be involved in schizophrenia. The linkage data thus provide unique new evidence that the α7-nicotinic receptor gene may be responsible for the inheritance of a pathophysiological aspect of the illness.
Starting Page	587
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	94
Language	English
Publisher	The National Academy of Sciences of the USA
Publisher Date	1997-01-21
Access Restriction	Open
Rights Holder	The National Academy of Sciences of the USA
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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