Loading...
Please wait, while we are loading the content...
Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels
| Content Provider | PubMed Central |
|---|---|
| Author | Angénieux, Catherine Fricker, Dominique Strub, Jean-marc Luche, Sylvie Bausinger, Huguette Cazenave, Jean-pierre Van, Dorsselaer Alain Hanau, Daniel Salle, Henri De La Thierry, Rabilloud |
| Abstract | Changes in gene expression occurring during differentiation of human monoytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions. These functions encompass of course antigen processing and presentation, cytoskeleton, cell signalling and signal transduction, but also an increase of mitochondrial function and of the protein synthesis machinery, including some, but not all, chaperones. These changes put in perspective the events occurring during this differentiation process. On a more technical point, it appears that the studies carried out at the RNA and protein levels are highly complementary. |
| Related Links | http://dx.doi.org/10.1007/s101420100037 |
| Ending Page | 329 |
| Page Count | 7 |
| Starting Page | 323 |
| File Format | |
| ISSN | 1438793X |
| e-ISSN | 14387948 |
| Journal | Functional & Integrative Genomics |
| Issue Number | 5 |
| Volume Number | 1 |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2001-09-01 |
| Access Restriction | Open |
| Rights Holder | Springer |
| Subject Keyword | Genetics Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Medicine |
