NDLI: Cross-Seeding and Cross-Competition in Mouse Apolipoprotein A-II Amyloid Fibrils and Protein A Amyloid Fibrils

Content Provider	PubMed Central
Author	Yan, Jingmin Fu, Xiaoying Ge, Fengxia Zhang, Beiru Yao, Junjie Zhang, Huanyu Qian, Jinze Hiroshi, Tomozawa Naiki, Hironobu Sawashita, Jinko Mori, Masayuki Higuchi, Keiichi
Copyright Year	2007
Abstract	Murine senile [apolipoprotein A-II amyloid (AApoAII)] and reactive [protein A amyloid (AA)] amyloidosis are reported to be transmissible diseases via a seeding mechanism similar to that observed in the prion-associated disorders, although de novo amyloidogenesis and the progression of AApoAII or AA amyloidosis remain unclear. We examined the effect of co-injection of AApoAII and AA fibrils and multiple inflammatory stimuli in R1.P1- Apoa2 c mice with the amyloidogenic Apoa2 c allele. Both AApoAII and AA amyloidosis could be induced in this system, but the two types of amyloid fibrils preferentially promote the formation of the same type of fibrils while inhibiting the formation of the other. Furthermore, we demonstrate that AA or AApoAII amyloidosis could be cross-seeded by predeposited AApoAII or AA fibrils and that the predeposited amyloid fibrils were degraded when the fibril formation was reduced or stopped. In addition, a large proportion of the two amyloid fibrils colocalized during the formation of new fibrils in the spleen and liver. Thus, we propose that AApoAII and AA can both cross-seed and cross-compete with regard to amyloid formation, depending on the stage of amyloidogenesis. These results will aid in the clarification of the mechanisms of pathogenesis and progression of amyloid disorders.
Related Links	http://dx.doi.org/10.2353/ajpath.2007.060576
Starting Page	172
File Format	PDF
ISSN	15252191
e-ISSN	15252191
Journal	The American Journal of Pathology
Issue Number	1
Volume Number	171
Language	English
Publisher	American Society for Investigative Pathology
Publisher Date	2007-07-01
Access Restriction	Open
Rights Holder	American Society for Investigative Pathology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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