NDLI: Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

Content Provider	PubMed Central
Author	Jan, Karlseder Kachatrian, Leili Takai, Hiroyuki Mercer, Kim Hingorani, Sunil Jacks, Tyler Lange, Titia De
Copyright Year	2003
Abstract	The human telomeric DNA binding factor TRF1 (hTRF1) and its interacting proteins TIN2, tankyrase 1 and 2, and PINX1 have been implicated in the regulation of telomerase-dependent telomere length maintenance. Here we show that targeted deletion of exon 1 of the mouse gene encoding Trf1 causes early (day 5 to 6 postcoitus) embryonic lethality. The absence of telomerase did not alter the Terf1ex1Δ/ex1Δ lethality, indicating that the phenotype was not due to inappropriate telomere elongation by telomerase. Terf1ex1Δ/ex1Δ blastocysts had a severe growth defect of the inner cell mass that was accompanied by apoptosis. However, no evidence was found for telomere uncapping causing this cell death; chromosome spreads of Terf1ex1Δ/ex1Δ blastocysts did not reveal chromosome end-to-end fusions, and p53 deficiency only briefly delayed Terf1ex1Δ/ex1Δ lethality. These data suggest that murine Trf1 has an essential function that is independent of telomere length regulation.
Related Links	http://dx.doi.org/10.1128/MCB.23.18.6533-6541.2003
Starting Page	6533
File Format	PDF
ISSN	10985549
e-ISSN	10985549
Journal	Molecular and Cellular Biology
Issue Number	18
Volume Number	23
Language	English
Publisher	American Society for Microbiology
Publisher Date	2003-09-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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Control of Human Telomere Length by TRF1 and TRF2

TRF1 Controls Telomere Length and Mitotic Fidelity in Epithelial Homeostasis▿ †

TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae.

Telomere Rapid Deletion Regulates Telomere Length in Arabidopsis thaliana ▿

Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1*

c-Myc interacts with TRF1/PIN2 and regulates telomere length

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex

Essential role of Pin1 in regulation of TRF1 stability and telomere maintenance

PinX1, a Telomere Repeat-binding Factor 1 (TRF1)-interacting Protein, Maintains Telomere Integrity by Modulating TRF1 Homeostasis, the Process in Which Human Telomerase Reverse Transcriptase (hTERT) Plays Dual Roles*

Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1

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Control of Human Telomere Length by TRF1 and TRF2

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Telomere Rapid Deletion Regulates Telomere Length in Arabidopsis thaliana ▿

Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1*

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Targeted Deletion Reveals an Essential Function for the Telomere Length Regulator Trf1