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| Content Provider | PubMed Central |
|---|---|
| Author | Kurrer, Michael o. Pakala, Syamasundar v. Hanson, Holly l. Katz, Jonathan d. |
| Copyright Year | 1997 |
| Abstract | Insulin-dependent diabetes mellitus results from T cell-mediated destruction of insulin-producing, pancreatic islet β cells. How this destruction takes place has remained elusive—largely due to the slow kinetics of disease progression. By crossing a transgenic mouse carrying a β cell-specific T cell receptor onto the NOD.scid background, we produced a simplified but robust and accelerated model of diabetes. This mouse produces CD4+ T cells bearing transgenic T cell receptor but is devoid of CD8+ T cells and B cells. More importantly, this mouse develops a rapid diabetes, which has allowed us to record and quantify β cell death. We have determined that β cells within the inflamed islets die by apoptosis. |
| Starting Page | 213 |
| File Format | |
| ISSN | 10916490 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 94 |
| Language | English |
| Publisher | The National Academy of Sciences of the USA |
| Publisher Date | 1997-01-07 |
| Access Restriction | Open |
| Rights Holder | The National Academy of Sciences of the USA |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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