NDLI: Primary CD8+ cells from HIV-infected individuals can suppress productive infection of macrophages independent of β-chemokines

Content Provider	PubMed Central
Author	Barker, Edward Bossart, Katharine N. Levy, Jay A.
Copyright Year	1998
Abstract	The productive infection of human monocyte-derived macrophages (Mφ) by HIV was suppressed by primary CD8+ cells from asymptomatic HIV-infected individuals. This anti-HIV response was noncytotoxic; removal of the CD8+ cells from the infected Mφ leads to virus production. CD8+ cells inhibited HIV replication when separated from the infected Mφ by a transwell filter insert, indicating a diffusible factor made by the CD8+ cells suppressed productive infection of Mφ. Three β-chemokines, which can be secreted by activated CD8+ cells, RANTES (regulated on activation normal T cell expressed and secreted), macrophage inflammatory protein (MIP)-1α and MIP-1β prevented HIV replication in the Mφ cultures. In addition, incubation of acutely infected Mφ with a mixture of neutralizing antibodies to RANTES, MIP-1α, and MIP-1β enhanced virus replication. Nevertheless, neutralization of β-chemokines with specific antibodies did not abolish the suppression by CD8+ cells of HIV replication in Mφ. Thus, even though β-chemokines decrease HIV replication in Mφ, these cytokines are not responsible for the ability of CD8+ cells to inhibit HIV production in these cells.
Starting Page	1725
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	95
Language	English
Publisher	The National Academy of Sciences
Publisher Date	1998-02-17
Access Restriction	Open
Rights Holder	The National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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