NDLI: Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis

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Polymorphisms in chemokine and chemokine receptor genes and the development of coal workers' pneumoconiosis

Content Provider	PubMed Central
Author	Nadif, Rachel Mintz, Margaret Selma, Rivas-fuentes Jedlicka, Anne Lavergne, Elise Rodero, Mathieu Kauffmann, Francine Christophe, Combadière Kleeberger, Steven R.
Abstract	Chemokines and their receptors are key regulators of inflammation and may participate in the lung fibrotic process. Associations of polymorphisms in CCL5 (G-403A) and its receptor CCR5 (Δ32), CCL2 (A-2578G) and CCR2 (V64I), and CX3CR1 V249I and T280M with Coal Worker’s Pneumoconiosis (CWP) were investigated in 209 miners examined in 1990, 1994 and 1999. Coal dust exposure was assessed by job history and ambient measures. The main health outcome was lung computed tomography (CT) score in 1990. Internal coherence was assessed by studying CT score in 1994, 4-year change in CT score, and CWP prevalence in 1999. CCR5 Δ32 carriers had significantly higher CT score in 1990 and 1994 (2.15 vs. 1.28, p=0.01; 3.04 vs. 1.80, p=0.04). The CX3CR1 1249 allele was significantly associated with lower 1990 CT score and lower progression in 4-year change in CT score in CCR5 Δ32 carriers only (p for interaction=0.03 and 0.02). CX3CR1 V249I was associated with lower 1999 CWP prevalence (16.7%, 13.2%, 0.0% for VV, VI and II); the effect was most evident in miners with high dust exposure (31.6%, 21.7%, 0.0%). Our findings indicate that chemokine receptors CCR5 and CX3CR1 may be involved in the development of pneumoconiosis.
Related Links	http://dx.doi.org/10.1016/j.cyto.2006.01.001
Ending Page	178
Page Count	8
Starting Page	171
File Format	PDF
ISSN	10434666
e-ISSN	10960023
Journal	Cytokine
Issue Number	3
Volume Number	33
Language	English
Publisher	Academic Press
Publisher Date	2006-02-07
Access Restriction	Open
Rights Holder	Academic Press
Subject Keyword	Immunology Immunology and Allergy Biochemistry Molecular Biology Hematology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Biochemistry Hematology Molecular Biology Immunology

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