NDLI: Axon Guidance Gene lola is Required for Programmed Cell Death in the Drosophila Ovary

Content Provider	PubMed Central
Author	Bass, B. Paige Cullen, Kristen Mccall, Kimberly
Abstract	longitudinals-lacking (lola) was identified in Drosophila as a gene encoding several alternatively spliced transcription factors involved in axon guidance. Here we report that lola also plays a critical role in programmed cell death in the ovary. lola mutant germline clones show a high percentage of egg chambers with nurse cell nuclei persisting past stage 13, indicating a block in developmental nurse cell death. Mutants also show a disruption in the induced programmed cell death that occurs during mid-oogenesis in response to starvation. Further characterization revealed that lola germline clones exhibit abnormal nuclear organization which becomes increasingly severe with age. Chromatin appears diffuse and fails to condense properly or undergo DNA fragmentation in dying nurse cells. Masses of nuclear material accumulate in the ovaries of older flies containing lola germline clones. We propose that lola is necessary for complete chromatin condensation which occurs during programmed cell death in the ovary. Alleles differed in the strength of their phenotypes but interestingly, the severity of their ovarian phenotypes was independent of the strength of their neuronal phenotypes, suggesting a differential requirement for individual lola isoforms in the ovary and nervous system.
Related Links	http://dx.doi.org/10.1016/j.ydbio.2007.01.029
Ending Page	785
Page Count	15
Starting Page	771
File Format	PDF
ISSN	00121606
e-ISSN	1095564X
Journal	Developmental biology
Issue Number	2
Volume Number	304
Language	English
Publisher Date	2007-04-01
Access Restriction	Open
Subject Keyword	Developmental Biology Cell Biology Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Cell Biology Developmental Biology Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

lola encodes a putative transcription factor required for axon growth and guidance in Drosophila

The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis

Drosophila semaphorin2b is Required for the Axon Guidance of a Subset of Embryonic Neurons

Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila

Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola

Robo2 is required for Slit-mediated intraretinal axon guidance

Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary

The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila

Drosophila Plexin B is a Sema-2a receptor required for axon guidance

Axon Guidance Gene lola is Required for Programmed Cell Death in the Drosophila Ovary

Similar Documents

lola encodes a putative transcription factor required for axon growth and guidance in Drosophila

The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis

Drosophila semaphorin2b is Required for the Axon Guidance of a Subset of Embryonic Neurons

Mushroom body defect is required in parallel to Netrin for midline axon guidance in Drosophila

Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola

Robo2 is required for Slit-mediated intraretinal axon guidance

Bcl-2 proteins and autophagy regulate mitochondrial dynamics during programmed cell death in the Drosophila ovary

The columnar gene vnd is required for tritocerebral neuromere formation during embryonic brain development of Drosophila

Drosophila Plexin B is a Sema-2a receptor required for axon guidance

Axon Guidance Gene lola is Required for Programmed Cell Death in the Drosophila Ovary