NDLI: Transcription-coupled deposition of histone modifications during MHC class II gene activation

Content Provider	PubMed Central
Author	Natalia, Rybtsova Leimgruber, Elisa Queralt, Seguin-estévez Isabelle, Dunand-sauthier Krawczyk, Michal Reith, Walter
Copyright Year	2007
Abstract	Posttranslational histone modifications associated with actively expressed genes are generally believed to be introduced primarily by histone-modifying enzymes that are recruited by transcription factors or their associated co-activators. We have performed a comprehensive spatial and temporal analyses of the histone modifications that are deposited upon activation of the MHC class II gene HLA-DRA by the co-activator CIITA. We find that transcription-associated histone modifications are introduced during two sequential phases. The first phase precedes transcription initiation and is characterized exclusively by a rapid increase in histone H4 acetylation over a large upstream domain. All other modifications examined, including the acetylation and methylation of several residues in histone H3, are restricted to short regions situated at or within the 5′ end of the gene and are established during a second phase that is concomitant with ongoing transcription. This second phase is completely abrogated when elongation by RNA polymerase II is blocked. These results provide strong evidence that transcription elongation can play a decisive role in the deposition of histone modification patterns associated with inducible gene activation.
Related Links	http://dx.doi.org/10.1093/nar/gkm214
Ending Page	3441
Page Count	11
Starting Page	3431
File Format	PDF
ISSN	03051048
e-ISSN	13624962
Journal	Nucleic Acids Research
Issue Number	10
Volume Number	35
Language	English
Publisher	Oxford University Press
Publisher Date	2007-04-01
Access Restriction	Open
Rights Holder	Oxford University Press
Subject Keyword	Genetics Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics

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