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Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison
| Content Provider | PubMed Central |
|---|---|
| Author | Chen, Christine Hiu-tung Zhang, Wei |
| Abstract | Reactions using fluorous reagents and scavengers are compared side-by-side with their solid-supported counterparts. Fluorous triphenylphosphine is used in the bromination reaction of alcohols, fluorous thiol is used as an electrophile scavenger for α-bromoketones, fluorous isatoic anhydride is used as a nucleophile scavenger for primary and secondary amines. Reactions involving fluorous reagents and scavengers occur in homogeneous media with solution-phase reaction kinetics. Reactions with solid-supported reagents and scavengers occur in a heterogeneous media, and the reaction kinetics is greatly affected by the nature of the solid-support and reaction environment. Significantly larger amounts of reagents and longer time are usually needed to complete the solid-supported reaction. |
| Related Links | http://dx.doi.org/10.1007/s11030-005-8104-3 |
| Ending Page | 359 |
| Page Count | 7 |
| Starting Page | 353 |
| File Format | |
| ISSN | 13811991 |
| Journal | Molecular diversity |
| Issue Number | 4 |
| Volume Number | 9 |
| Language | English |
| Publisher Date | 2005-11-01 |
| Access Restriction | Open |
| Subject Keyword | Physical and Theoretical Chemistry Inorganic Chemistry Organic Chemistry Molecular Biology Drug Discovery Catalysis Information Systems Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Medicine Drug Discovery Molecular Biology Physical and Theoretical Chemistry Information Systems Catalysis Inorganic Chemistry |
