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| Content Provider | PubMed Central |
|---|---|
| Author | Nguyen, H. Silny, J. Wuller, S. Marschall, H. Rau, G. Matern, S. |
| Abstract | Abstract Background—Patients with long standing diabetesmellitus frequently have upper gut dysmotility. Gastroparesis has beenwell studied, whereas detailed data on duodenal motor function are limited. Aims —To characterise postprandialduodenal chyme transport in such patients. Methods —Intraluminal multipleimpedance measurement, recently introduced as a novel technique forinvestigation of chyme transport, was used to study postprandialduodenal chyme flow in 10 patients with long standing insulin dependentdiabetes mellitus with gastroparesis, and 10 healthy volunteers. Results—Four distinct transport patterns ofchyme, termed bolus transport events (BTEs), were found in both groupsand could be characterised as: short distance propulsive; simple longdistance propulsive; retrograde; and complex long distance propulsive. Diabetic patients had significantly lower numbers of propulsive BTEs(p<0.01), and higher proportions of retrograde BTEs and complex longdistance BTEs (p<0.05) than control subjects, whereas the proportionof simple long distance BTEs was significantly lower (p<0.05). Themean propagation velocities of the BTEs were similar in both groups. Conclusion—Abnormal postprandial duodenal chymetransport was found in patients with long standing insulin dependentdiabetes mellitus. This is characterised by transport disorganisationand may result in disturbed chyme clearance. |
| Starting Page | 624 |
| File Format | |
| ISSN | 14583288 |
| e-ISSN | 14583288 |
| Journal | Gut |
| Issue Number | 5 |
| Volume Number | 41 |
| Language | English |
| Publisher Date | 1997-11-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
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