NDLI: A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge.

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Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses.

Specific binding of host cellular proteins to multiple sites within the 3' end of mouse hepatitis virus genomic RNA.

Characterization of an infectious molecular clone of human T-cell leukemia virus type I.

Molecular and biological analyses of quasispecies during evolution of a virulent simian immunodeficiency virus, SIVsmmPBj14.

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Cytomegalovirus-mediated induction of antisense mRNA expression to UL44 inhibits virus replication in an astrocytoma cell line: identification of an essential gene.

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Structural analysis of the principal immunodominant domain of the feline immunodeficiency virus transmembrane glycoprotein.

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Replication of macrophage-tropic and T-cell-tropic strains of human immunodeficiency virus type 1 is augmented by macrophage-endothelial cell contact.

Detection of truncated virus particles in a persistent RNA virus infection in vivo.

Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor.

Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice.

Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function.

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Secondary structure model of the Mason-Pfizer monkey virus 5' leader sequence: identification of a structural motif common to a variety of retroviruses.

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Physical association of moesin and CD46 as a receptor complex for measles virus.

Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery.

In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.

Characterization of neutralization epitopes in the V2 region of human immunodeficiency virus type 1 gp120: role of glycosylation in the correct folding of the V1/V2 domain.

A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge.

Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child.

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Longitudinal assessment of feline immunodeficiency virus kinetics in plasma by use of a quantitative competitive reverse transcriptase PCR.

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Intraspecific phylogenetics: support for dental transmission of human immunodeficiency virus.

Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro.

Sequence requirements for encapsidation of deletion mutants and chimeras of human immunodeficiency virus type 1 Gag precursor into retrovirus-like particles.

Progression to AIDS in the absence of a gene for vpr or vpx.

Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection.

Increased adhesion as a mechanism of antibody-dependent and antibody-independent complement-mediated enhancement of human immunodeficiency virus infection.

Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus.

Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1.

Functional cDNA clones of the human respiratory syncytial (RS) virus N, P, and L proteins support replication of RS virus genomic RNA analogs and define minimal trans-acting requirements for RNA replication.

Individual expression of influenza virus PA protein induces degradation of coexpressed proteins.

Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs.

The JC virus minimal core promoter is glial cell specific in vivo.

The majority of cells are superinfected in a cloned cell line that produces high levels of human immunodeficiency virus type 1 strain MN.

Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions.

Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules.

Mutations in the putative fusion peptide of Semliki Forest virus affect spike protein oligomerization and virus assembly.

Tyrosine phosphorylation of measles virus nucleocapsid protein in persistently infected neuroblastoma cells.

Multiple regions of Harvey sarcoma virus RNA can dimerize in vitro.

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis.

Functional domains of delta antigens and viral RNA required for RNA packaging of hepatitis delta virus.

Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation.

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Effect of cellular differentiation on cytokine-induced expression of human immunodeficiency virus in chronically infected promonocytic cells: dissociation of cellular differentiation and viral expression.

Mutations in the helicase-like domain of protein 1a alter the sites of RNA-RNA recombination in brome mosaic virus.

Conservation of an intact human immunodeficiency virus type 1 vif gene in vitro and in vivo.

Tetracycline repressor-regulated gene repression in recombinant human cytomegalovirus.

DNA vaccination against persistent viral infection.

Identification of a membrane fusion domain and an oligomerization domain in the baculovirus GP64 envelope fusion protein.

Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1.

The H4 subunit of vaccinia virus RNA polymerase is not required for transcription initiation at a viral late promoter.

Delineating minimal protein domains and promoter elements for transcriptional activation by lentivirus Tat proteins.

Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy.

Chromosome mapping of Rfv3, a host resistance gene to Friend murine retrovirus.

Simian AIDS type D serogroup 2 retrovirus: isolation of an infectious molecular clone and sequence analyses of its envelope glycoprotein gene and 3' long terminal repeat.

Mapping the hemagglutination domain of rotaviruses.

An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP gene.

Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals.

The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter.

Epstein-Barr virus lytic replication is controlled by posttranscriptional negative regulation of BZLF1.

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax.

Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.

Retroviral vector particles displaying the antigen-binding site of an antibody enable cell-type-specific gene transfer.

Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells.

Respiratory syncytial virus matures at the apical surfaces of polarized epithelial cells.

Varicella-zoster virus (VZV) transcription during latency in human ganglia: prevalence of VZV gene 21 transcripts in latently infected human ganglia.

Molecular characterization of the 3' terminus of the simian hemorrhagic fever virus genome.

DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection.

A spontaneous mutation in the movement protein gene of brome mosaic virus modulates symptom phenotype in Nicotiana benthamiana.

Symmetric-strand packaging of recombinant parvovirus LuIII genomes that retain only the terminal regions.

Encephalomyocarditis viruses with short poly(C) tracts are more virulent than their mengovirus counterparts.

Impairment of multicycle influenza virus growth in Vero (WHO) cells by loss of trypsin activity.

Identification of two separable modules in the duck hepatitis B virus core protein.

Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.

Papilloma formation in human foreskin xenografts after inoculation of human papillomavirus type 16 DNA.

Requirements for the self-directed replication of flock house virus RNA 1.

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A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge.

Content Provider	PubMed Central
Author	Yasutomi, Y. Koenig, S. Woods, R. M. Madsen, J. Wassef, N. M. Alving, C. R. Klein, H. J. Nolan, T. E. Boots, L. J. Kessler, J. A.
Abstract	Protection against simian immunodeficiency virus (SIV) challenge was assessed in rhesus monkeys with a vaccine-elicited, single SIV epitope-specific cytotoxic T-lymphocyte (CTL) response in the absence of SIV-specific antibody. Strategies were first explored for eliciting an optimal SIV Gag epitope-specific CTL response. These studies were performed in rhesus monkeys expressing the major histocompatibility complex (MHC) class I gene Mamu-A*01, a haplotype associated with a predominant SIV CTL epitope mapped to residues 182 to 190 of the Gag protein (p11C). We demonstrated that a combined modality immunization strategy using a recombinant Mycobacterium bovis BCG-SIV Gag construct for priming, and peptide formulated in liposome for boosting, elicited a greater p11C-specific CTL response than did a single immunization with peptide-liposome alone. Vaccinated and control monkeys were then challenged with cell-free SIVmne by an intravenous route of inoculation. Despite a vigorous p11C-specific CTL response at the time of virus inoculation, all monkeys became infected with SIV. gag gene sequencing of the virus isolated from these monkeys demonstrated that the established viruses had no mutations in the p11C-coding region. Thus, the preexisting CTL response did not select for a viral variant that might escape T-cell immune recognition. These studies demonstrate that a potent SIV-specific CTL response can be elicited by combining live vector and peptide vaccine modalities. However, a single SIV Gag epitope-specific CTL response in the absence of SIV-specific antibody did not provide protection against a cell-free, intravenous SIV challenge.
Starting Page	2279
File Format	PDF
ISSN	10985514
e-ISSN	10985514
Journal	Journal of Virology
Issue Number	4
Volume Number	69
Language	English
Publisher Date	1995-04-01
Access Restriction	Open
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology Insect Science

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