NDLI: Functional redundancy of worm spliceosomal proteins U1A and U2B″

Content Provider	PubMed Central
Author	Saldi, Tassa Wilusz, Carol Margaret, Macmorris Blumenthal, Thomas
Copyright Year	2007
Abstract	In Caenorhabditis elegans, the small nuclear ribonucleoprotein (snRNP)-associated proteins U1A and U2B″ are ≈50% identical to each other, and neither bears signature characteristics of mammalian U1A or U2B″ or the single Drosophila homolog, SNF. We show here that the genes that encode these proteins (rnp-2 and rnp-3) are cotranscribed in an operon, and that ribonucleoprotein RNP-2 is U1 snRNP-associated (U1A) whereas RNP-3 is U2 snRNP-associated (U2B″). U2B″ interacts with U2 even in the absence of another U2 snRNP protein, U2A′. Like U1A and U2B″ from yeast, plants, and vertebrates, worm U1A and U2B″ are more similar to each other than they are to other U1A or U2B″ proteins, respectively. Even though U1A and U2B″ interact with different snRNPs, they are functionally redundant; knockout of both is required for a lethal phenotype. Interestingly, U1A associates with U2 RNA when U2B″ is deleted. Thus, the two members of this gene family normally function as components of different snRNPs but apparently remain capable of performing the function of the other. Redundancy results from the fact that one protein can substitute for the other, even though it normally does not.
Related Links	http://dx.doi.org/10.1073/pnas.0701720104
Ending Page	9757
Page Count	5
Starting Page	9753
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	104
Language	English
Publisher	National Academy of Sciences
Publisher Date	2007-06-05
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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