NDLI: Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses

Content Provider	PubMed Central
Author	Tecuapetla, Fatuel Luis, Carrillo-reid Bargas, José Galarraga, Elvira
Copyright Year	2007
Abstract	Circuit properties, such as the selection of motor synergies, have been posited as relevant tasks for the recurrent inhibitory synapses between spiny projection neurons of the neostriatum, a nucleus of the basal ganglia participating in procedural learning and voluntary motor control. Here we show how the dopaminergic system regulates short-term plasticity (STP) in these synapses. STP is thought to endow neuronal circuits with computational powers such as gain control, filtering, and the emergence of transitory net states. But little is known about STP regulation. Employing unitary and population synaptic recordings, we observed that activation of dopamine receptors can modulate STP between spiny neurons. A D1-class agonist enhances, whereas a D2-class agonist decreases, short-term depression most probably by synaptic redistribution. Presynaptic receptors appear to be responsible for this modulation. In contrast, STP between fast-spiking interneurons and spiny projection neurons is largely unregulated despite expressing presynaptic receptors. Thus, the present experiments provide an explanation for dopamine actions at the circuit level: the control of STP between lateral connections of output neurons and the reorganization of the balance between different forms of inhibitory transmission. Theoretically, D1 receptors would promote a sensitive, responsive state for temporal precision (dynamic component), whereas D2 receptors would sense background activity (static component).
Related Links	http://dx.doi.org/10.1073/pnas.0703813104
Ending Page	10263
Page Count	6
Starting Page	10258
File Format	PDF
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	104
Language	English
Publisher	National Academy of Sciences
Publisher Date	2007-06-12
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	General Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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