NDLI: Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1α

Content Provider	PubMed Central
Author	Magnon, Claire Paule, Opolon Ricard, Marcel Elisabeth, Connault Ardouin, Patrice Ariane, Galaup Didier, Métivier Bidart, Jean-michel Germain, Stéphane Michel, Perricaudet Schlumberger, Martin
Copyright Year	2007
Abstract	Tumor radioresponsiveness depends on endothelial cell death, which leads in turn to tumor hypoxia. Radiation-induced hypoxia was recently shown to trigger tumor radioresistance by activating angiogenesis through hypoxia-inducible factor 1–regulated (HIF-1–regulated) cytokines. We show here that combining targeted radioiodide therapy with angiogenic inhibitors, such as canstatin, enhances direct tumor cell apoptosis, thereby overcoming radio-induced HIF-1–dependent tumor survival pathways in vitro and in vivo. We found that following dual therapy, HIF-1α increases the activity of the canstatin-induced αvβ5 signaling tumor apoptotic pathway and concomitantly abrogates mitotic checkpoint and tetraploidy triggered by radiation. Apoptosis in conjunction with mitotic catastrophe leads to lethal tumor damage. We discovered that HIF-1 displays a radiosensitizing activity that is highly dependent on treatment modalities by regulating key apoptotic molecular pathways. Our findings therefore support a crucial role for angiogenesis inhibitors in shifting the fate of radiation-induced HIF-1α activity from hypoxia-induced tumor radioresistance to hypoxia-induced tumor apoptosis. This study provides a basis for developing new biology-based clinically relevant strategies to improve the efficacy of radiation oncology, using HIF-1 as an ally for cancer therapy.
Related Links	http://dx.doi.org/10.1172/jci30269
Ending Page	1855
Page Count	12
Starting Page	1844
File Format	PDF
ISSN	00219738
Journal	Journal of Clinical Investigation
Issue Number	7
Volume Number	117
Language	English
Publisher	American Society for Clinical Investigation
Publisher Date	2007-07-02
Access Restriction	Open
Rights Holder	American Society for Clinical Investigation
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Medicine

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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