NDLI: Saccadic latency distributions in Parkinson's disease and the effects of l-dopa

Content Provider	PubMed Central
Author	Michell, A. W. Xu, Z. Fritz, D. Lewis, S. J. G. Foltynie, T. Williams-gray, C. H. Robbins, T. W. Carpenter, R. H. S. Barker, R. A.
Abstract	Parkinson's disease (PD) is associated with a loss of central dopaminergic pathways in the brain leading to an abnormality of movement, including saccades. In PD, analysis of saccadic latency distributions, rather than mean latencies, can provide much more information about how the neural decision process that precedes movement is affected by disease or medication. Subject to the constraints of intersubject variation and reproducibility, latency distribution may represent an attractive potential biomarker of PD. Here we report two studies that provide information about these parameters, and demonstrate a novel effect of dopamine on saccadic latency, implying that it influences the neural decision process itself. We performed a detailed cross-sectional study of saccadic latency distributions during a simple step task in 22 medicated patients and 27 age-matched controls. This revealed high intersubject variability and an overlap of PD and control distributions. A second study was undertaken on a different population specifically to investigate the effects of dopamine on saccadic latency distributions in 15 PD patients. l-dopa was found to prolong latency, although the magnitude of the effect varied between subjects. The implications of these observations for the use of saccadic latency distributions as a potential biomarker of PD are discussed, as are the effects of l-dopa on neural decision making, where it is postulated to increase the criterion level of evidence required before the decision to move is made.
Related Links	http://dx.doi.org/10.1007/s00221-006-0412-z
Ending Page	18
Page Count	12
Starting Page	7
File Format	PDF
ISSN	00144819
e-ISSN	14321106
Journal	Experimental brain research. Experimentelle Hirnforschung. Experimentation cerebrale
Issue Number	1
Volume Number	174
Language	English
Publisher Date	2006-09-01
Access Restriction	Open
Subject Keyword	Neuroscience(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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