NDLI: Dystroglycan Expression Is Frequently Reduced in Human Breast and Colon Cancers and Is Associated with Tumor Progression

Content Provider	PubMed Central
Author	Sgambato, Alessandro Mario, Migaldi Montanari, Micaela Camerini, Andrea Brancaccio, Andrea Rossi, Giulio Cangiano, Rodolfo Carmen, Losasso Capelli, Giovanni Trentini, Gian Paolo Cittadini, Achille
Abstract	Dystroglycan (DG) is an adhesion molecule responsible for crucial interactions between extracellular matrix and cytoplasmic compartment. It is formed by two subunits, α-DG (extracellular) and β-DG (transmembrane), that bind to laminin in the matrix and dystrophin in the cytoskeleton, respectively. In this study we evaluated by Western blot analysis the expression of DG in a series of human cancer cell lines of various histogenetic origin and in a series of human primary colon and breast cancers. Decreased expression of DG was observed in most of the cell lines and in both types of tumors and correlated with higher tumor grade and stage. Analysis of the mRNA levels suggested that expression of DG protein is likely regulated at a posttranscriptional level. Evaluation of α-DG expression by immunostaining in a series of archival cases of primary breast carcinomas confirmed that α-DG expression is lost in a significant fraction of tumors (66%). Loss of DG staining correlated with higher tumor stage ( P = 0.022), positivity for p53 ( P = 0.033), and high proliferation index ( P = 0.045). A significant correlation was also observed between loss of α-DG and overall survival ( P = 0.013 by log-rank test) in an univariate analysis. These data indicate that DG expression is frequently lost in human malignancies and suggest that this glycoprotein might play an important role in human tumor development and progression.
Related Links	http://dx.doi.org/10.1016/s0002-9440(10)63881-3
Ending Page	860
Page Count	12
Starting Page	849
File Format	PDF
ISSN	00029440
e-ISSN	15252191
Journal	The American Journal of Pathology
Issue Number	3
Volume Number	162
Language	English
Publisher	American Society for Investigative Pathology
Publisher Date	2003-03-01
Access Restriction	Open
Rights Holder	American Society for Investigative Pathology
Subject Keyword	Pathology and Forensic Medicine Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

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