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| Content Provider | PubMed Central |
|---|---|
| Author | Bourgain, Catherine |
| Copyright Year | 2005 |
| Abstract | In this paper, different strategies to test for association in samples with related individuals designed for linkage studies are compared. Because no independent controls are available, a family-based association test and case-control tests corrected for the presence of related individuals in which unaffected relatives are used as controls were tested. When unrelated controls are available, additional strategies including selection of a single case per family considering either all families or a subset of linked families, are also considered. Analyses are performed on the simulated dataset, blind to the answers. The case-control test corrected for the presence of related individuals is the most powerful strategy to detect three loci associated with the disease under study. Using a correction factor for the case-control test performed conditional on the marker information rather than unconditional does not impact the power significantly. |
| Related Links | http://dx.doi.org/10.1186/1471-2156-6-s1-s98 |
| Starting Page | 98 |
| File Format | |
| ISSN | 14712156 |
| e-ISSN | 14712156 |
| Journal | BMC Genetics |
| Issue Number | Suppl 1 |
| Volume Number | 6 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2005-01-01 |
| Access Restriction | Open |
| Rights Holder | BioMed Central |
| Subject Keyword | Genetics(clinical) Genetics Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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