NDLI: Pneumococcal Capsular Polysaccharide Vaccine-Mediated Protection against Serotype 3 Streptococcus pneumoniae in Immunodeficient Mice▿

Content Provider	PubMed Central
Author	Tian, Haijun Groner, Avi Boes, Marianne Pirofski, Liise-anne
Copyright Year	2007
Abstract	Pneumococcal capsular polysaccharide (PPS) vaccines are less immunogenic in immunocompromised than immunocompetent individuals. However, neither the efficacy of PPS vaccines in immunocompromised individuals nor the host cellular subsets required for vaccine efficacy against pneumococcal disease have been directly investigated. In this study, we vaccinated CD4-deficient (CD4−/−), CD8-deficient (CD8−/−), and secretory immunoglobulin M-deficient (sIgM−/−) mice and wild-type C57BL/6 (Wt) mice with a conjugate of PPS of serotype 3 and tetanus toxoid (PPS3-TT) and determined the antibody response and efficacy of vaccination against systemic and pulmonary challenge with serotype 3 pneumococcus in immunized and control mice. Our results showed that the isotype and predominant IgG subclass of the PPS3 response differed between immunodeficient mouse strains and between immunodeficient and Wt mice, with CD8−/− mice having the most robust response. Vaccination protected Wt, CD4−/−, and sIgM−/− mice from death resulting from both systemic and pulmonary challenge, whereas CD8−/− mice were protected only from systemic and not from pulmonary challenge. Passive vaccination with PPS3-TT-induced sera from Wt, CD4−/−, CD8−/−, and sIgM−/− mice protected naïve Wt mice from death due to pulmonary challenge; however, CD8−/− mice were not protected by sera from Wt or CD8−/− mice. Our findings suggest that PPS-based vaccines can be effective in the setting of CD4 T-cell deficiency but that CD8 T cells could be required for vaccine-mediated protection against pulmonary challenge with serotype 3 pneumococcus.
Related Links	http://dx.doi.org/10.1128/iai.01371-06
Ending Page	1650
Page Count	8
Starting Page	1643
File Format	PDF
ISSN	00199567
e-ISSN	10985522
Journal	Infection and Immunity
Issue Number	4
Volume Number	75
Language	English
Publisher	American Society for Microbiology
Publisher Date	2007-04-01
Access Restriction	Open
Rights Holder	American Society for Microbiology
Subject Keyword	Immunology Microbiology Parasitology Infectious Diseases Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology

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