Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | PubMed Central |
|---|---|
| Author | Ito, Y. Suzuki, H. Aizawa, H. Hakoda, H. Hirose, T. |
| Abstract | 1. Tissue taken at operation was used to study the electrical and mechanical properties of human bronchial smooth muscle with intracellular microelectrodes and isometric recording of tension changes. 2. Over 90% of the muscle strips exhibited spontaneous tone and 70% produced spontaneous phasic contractions. The resting membrane potential of the smooth muscle cells ranged between -40 to -50 mV with a mean value of -44.9 +/- 5.2 mV (n = 92 +/- s.d.). Spontaneous oscillations of the membrane potential (slow waves) were observed in 90% of the cells examined. 3. The electrical slow waves, phasic contractions and spontaneous tone were greatly reduced by FPL 55712 (10(-6)-10(-5) M). Indomethacin (1-5 x 10(-5) M), atropine (10(-6) M) or a 5-lipoxygenase inhibitor, AA 861 (5 x 10(-6) M) each reduced spontaneous mechanical tone. Indomethacin and atropine each caused minor reduction in the amplitude of electrical slow waves. 4. Leukotriene C4 (10(-8) M), physostigmine (10(-6) M) and K+-rich physiological salt-solution (containing atropine 10(-6) M) each caused tone development in tissue treated with AA 861 (5 x 10(-6) M). In the case of leukotriene C4 and physostigmine, phasic contractions were superimposed on the developed tone. 5. Electrical field stimulation evoked an excitatory junction potential (e.j.p.) followed by a small group of slow waves. Repetitive field stimulation (2-20 stimuli at 20 Hz) markedly enhanced the amplitude of oscillatory slow waves. FPL 55712 (1.9 x 10(-6) M) abolished the oscillatory slow waves following the e.j.p., and physostigmine (10(-6) M) enhanced the amplitude of the e.j.p. and slow waves. 6. These results indicate that, under in vitro conditions, the electrical activity of human bronchial smooth muscle comprises slow wave discharge which may be related to the spontaneous contractions and generation of basal tone. |
| Starting Page | 1249 |
| File Format | |
| ISSN | 00071188 |
| Journal | British Journal of Pharmacology |
| Issue Number | 4 |
| Volume Number | 98 |
| Language | English |
| Publisher Date | 1989-12-01 |
| Access Restriction | Open |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|