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| Content Provider | PubMed Central |
|---|---|
| Author | Reich, David Patterson, Nick Ramesh, Vijaya Jager, Philip L. De Mcdonald, Gavin J. Tandon, Arti Choy, Edwin Hu, Donglei Tamraz, Bani Pawlikowska, Ludmila Christina, Wassel-fyr Huntsman, Scott Waliszewska, Alicja Rossin, Elizabeth Li, Rongling Garcia, Melissa Reiner, Alexander Ferrell, Robert Cummings, Steve Kwok, Pui-yan Harris, Tamara Zmuda, Joseph M. Ziv, Elad |
| Copyright Year | 2007 |
| Abstract | Circulating levels of inflammatory markers can predict cardiovascular disease risk. To identify genes influencing the levels of these markers, we genotyped 1,343 single-nucleotide polymorphisms (SNPs) in 1,184 African Americans from the Health, Aging and Body Composition (Health ABC) Study. Using admixture mapping, we found a significant association of interleukin 6 soluble receptor (IL-6 SR) with European ancestry on chromosome 1 (LOD 4.59), in a region that includes the gene for this receptor (IL-6R). Genotyping 19 SNPs showed that the effect is largely explained by an allele at 4% frequency in West Africans and at 35% frequency in European Americans, first described as associated with IL-6 SR in a Japanese cohort. We replicate this association ( P≪1.0×10-12 ) and also demonstrate a new association with circulating levels of a different molecule, IL-6 ( P<3.4×10-5 ). After replication in 1,674 European Americans from Health ABC, the combined result is even more significant: P≪1.0×10-12 for IL-6 SR, and P<2.0×10-9 for IL-6. These results also serve as an important proof of principle, showing that admixture mapping can not only coarsely localize but can also fine map a phenotypically important variant. |
| Starting Page | 716 |
| File Format | |
| ISSN | 15376605 |
| e-ISSN | 15376605 |
| Journal | American Journal of Human Genetics |
| Issue Number | 4 |
| Volume Number | 80 |
| Language | English |
| Publisher | American Society of Human Genetics |
| Publisher Date | 2007-04-01 |
| Access Restriction | Open |
| Rights Holder | American Society of Human Genetics |
| Subject Keyword | Research in Higher Education |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Genetics (clinical) |
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