NDLI: Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

Please wait, while we are loading the content...

A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development

Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing

U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53

Decline in ribosomal fidelity contributes to the accumulation and stabilization of the master stress response regulator σS upon carbon starvation

Addendum

Year: 2007, Volume: 21, Issue: 6

Year: 2007, Volume: 21, Issue: 5

Year: 2007, Volume: 21, Issue: 4

Year: 2007, Volume: 21, Issue: 3

Year: 2007, Volume: 21, Issue: 2

Year: 2007, Volume: 21, Issue: 1

Year: 2006, Volume: 20

Year: 2005, Volume: 19

Year: 2004, Volume: 18

Year: 2003, Volume: 17

Year: 2002, Volume: 16

Year: 2001, Volume: 15

Year: 2000, Volume: 14

Year: 1999, Volume: 13

Year: 1998, Volume: 12

Year: 1997, Volume: 11

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

Content Provider	PubMed Central
Author	Tanny, Jason C. Erdjument-bromage, Hediye Paul, Tempst Allis, C. David
Copyright Year	2007
Abstract	Transcription by RNA polymerase II (polII) is accompanied by dramatic changes in chromatin structure. Numerous enzymatic activities contribute to these changes, including ATP-dependent nucleosome remodeling enzymes and histone modifying enzymes. Recent studies in budding yeast document a histone modification pathway associated with polII transcription, whereby ubiquitylation of histone H2B leads to methylation of histone H3 on specific lysine residues. Although this series of events appears to be highly conserved among eukaryotes, its mechanistic function in transcription is unknown. Here we document a significant functional divergence between ubiquitylation of H2B and methylation of Lys 4 on histone H3 in the fission yeast Schizosaccharomyces pombe. Loss of H2B ubiquitylation results in defects in cell growth, septation, and nuclear structure, phenotypes not observed in cells lacking H3 Lys 4 methylation. Consistent with these results, gene expression microarray analysis reveals a greater role for H2B ubiquitylation in gene regulation than for H3 Lys 4 methylation. Chromatin immunoprecipitation (ChIP) experiments demonstrate that loss of H2B ubiquitylation alters the distribution of polII and histones in gene coding regions. We propose that ubiquitylation of H2B impacts transcription elongation and nuclear architecture through its effects on chromatin dynamics.
Related Links	http://dx.doi.org/10.1101/gad.1516207
Ending Page	847
Page Count	13
Starting Page	835
File Format	PDF
ISSN	08909369
e-ISSN	15495477
Journal	Genes & Development
Issue Number	7
Volume Number	21
Language	English
Publisher	Cold Spring Harbor Laboratory Press
Publisher Date	2007-04-01
Access Restriction	Open
Rights Holder	Cold Spring Harbor Laboratory Press
Subject Keyword	Medicine(all) Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Genetics Developmental Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

Histone H2B Ubiquitylation Is Associated with Elongating RNA Polymerase II

PDX-1 LINKS HISTONE H3-LYS4 METHYLATION TO RNA POLYMERASE II ELONGATION DURING ACTIVATION OF INSULIN TRANSCRIPTION*

Histone H2B Monoubiquitylation Regulates Elongation-to-Termination Transition in RNA Polymerase II Transcription

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription

Histone H2B Ubiquitylation Is Not Required for Histone H3 Methylation at Lysine 4 in Tetrahymena

Pdx-1 Links Histone H3-Lys-4 Methylation to RNA Polymerase II Elongation during Activation of Insulin Transcription

Chd1 co-localizes with early transcription elongation factors independently of H3K36 methylation and releases stalled RNA polymerase II at introns

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

Similar Documents

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

Histone H2B Ubiquitylation Is Associated with Elongating RNA Polymerase II

PDX-1 LINKS HISTONE H3-LYS4 METHYLATION TO RNA POLYMERASE II ELONGATION DURING ACTIVATION OF INSULIN TRANSCRIPTION*

Histone H2B Monoubiquitylation Regulates Elongation-to-Termination Transition in RNA Polymerase II Transcription

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription

Histone H2B Ubiquitylation Is Not Required for Histone H3 Methylation at Lysine 4 in Tetrahymena

Pdx-1 Links Histone H3-Lys-4 Methylation to RNA Polymerase II Elongation during Activation of Insulin Transcription

Chd1 co-localizes with early transcription elongation factors independently of H3K36 methylation and releases stalled RNA polymerase II at introns

Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation