NDLI: Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans

Content Provider	PubMed Central
Author	Kostas, Tsintzas Jewell, Kirsty Kamran, Mo Laithwaite, David Boonsong, Tantip Littlewood, Julie Macdonald, Ian Bennett, Andrew
Copyright Year	2006
Abstract	This study investigated the molecular alterations underlying the physiological adaptations to starvation and refeeding in human skeletal muscle. Forty-eight hours' starvation reduced whole-body insulin sensitivity by 42% and produced marked changes in expression of key carbohydrate (CHO) regulatory genes and proteins: SREBP1c and hexokinase II (HKII) were downregulated 2.5- and 5-fold, respectively, whereas the pyruvate dexydrogenase kinase 4 (PDK4) was upregulated 4-fold. These responses were not dependent on the phosphorylation status of Akt and FOXO1. On the other hand, starvation and the concomitant increase in circulating free fatty acids did not upregulate the expression of transcription factors and genes involved in fat metabolism. Twenty-four hours' refeeding with a CHO-rich diet completely reversed the changes in PDK4, HKII and SREBP1c expression in human skeletal muscle but failed to fully restore whole-body insulin sensitivity. Thus, during starvation in healthy humans, unlike rodents, regulation of fat metabolism does not require an adaptive response at transcriptional level, but adaptive changes in gene expression are required to switch off oxidative glucose disposal. Lack of effect on key proteins in the insulin-signalling pathway may indicate that changes in intracellular substrate availability/flux may be responsible for these adaptive changes in glucose metabolism. This may represent an important aspect of the molecular basis of the development of insulin resistance in metabolic conditions characterized by energy restriction.
Related Links	http://dx.doi.org/10.1113/jphysiol.2006.109892
Ending Page	303
Page Count	13
Starting Page	291
File Format	PDF
ISSN	00223751
e-ISSN	14697793
Journal	The Journal of Physiology
Issue Number	Pt 1
Volume Number	575
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2006-08-15
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Physiology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Physiology Sports Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Metabolic Regulation of Ca2+ Release in Permeabilized Mammalian Skeletal Muscle Fibres

Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise

Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle

Myocardial and skeletal muscle glucose uptake during exercise in humans

Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects.

Skeletal muscle vasodilatation during sympathoexcitation is not neurally mediated in humans

Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans

Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans

Similar Documents

Metabolic Regulation of Ca2+ Release in Permeabilized Mammalian Skeletal Muscle Fibres

Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise

Effect of Short-Term Fasting and Refeeding on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle

Myocardial and skeletal muscle glucose uptake during exercise in humans

Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects.

Skeletal muscle vasodilatation during sympathoexcitation is not neurally mediated in humans

Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes

Regulation of capillary blood flow and oxygen supply in skeletal muscle in dogs during hypoxaemia.

Adrenaline and glycogenolysis in skeletal muscle during exercise: a study in adrenalectomised humans

Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans