NDLI: Use of cell permeable NBD peptides for suppression of inflammation

Content Provider	PubMed Central
Author	Ghosh, S. Strickland, I.
Abstract	Nuclear factor (NF)‐κB is a ubiquitous and essential transcription factor whose dysregulation has been linked to numerous diseases including arthritis and cancer. It is therefore not surprising that the NF‐κB activation pathway has become a major target for development of novel therapies for inflammatory diseases and cancer. However, the indispensable role played by NF‐κB in many biological processes has raised concern that a complete shutdown of this pathway would have significant detrimental effects on normal cellular function. Instead, drugs that selectively target the inflammation induced NF‐κB activity, while sparing the protective functions of basal NF‐κB activity, would be of greater therapeutic value and would likely display fewer undesired side effects. The recent identification and characterisation of the NF‐κB essential modulator (NEMO)‐binding domain (NBD) peptide that can block the activation of the IκB kinase (IKK) complex, have provided an opportunity to selectively abrogate the inflammation induced activation of NF‐κB by targeting the NBD–NEMO interaction. This peptide is synthesised in tandem with a protein transduction domain sequence from Drosophila antennapedia which facilitates uptake of the inhibitory peptide into the cytosol of target cells.
Related Links	http://dx.doi.org/10.1136/ard.2006.058438
Starting Page	75
File Format	PDF
ISSN	00034967
e-ISSN	14682060
Journal	Annals of the Rheumatic Diseases
Issue Number	Suppl 3
Volume Number	65
Language	English
Publisher	BMJ Group
Publisher Date	2006-11-01
Access Restriction	Open
Rights Holder	BMJ Group
Subject Keyword	Immunology Biochemistry, Genetics and Molecular Biology(all) Immunology and Allergy Rheumatology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Biochemistry, Genetics and Molecular Biology Immunology Rheumatology

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