NDLI: Role for rearranged variable gene segments in directing secondary T cell receptor α recombination

Content Provider	PubMed Central
Author	Abbas, Hawwari Krangel, Michael S.
Copyright Year	2007
Abstract	During the recombination of variable (V) and joining (J) gene segments at the T cell receptor α locus, a VαJα joint resulting from primary rearrangement can be replaced by subsequent rounds of secondary rearrangement that use progressively more 5′ Vα segments and progressively more 3′ Jα segments. To understand the mechanisms that target secondary T cell receptor α recombination, we studied the behavior of a T cell receptor α allele (HYα) engineered to mimic a natural primary rearrangement of TRAV17 to Jα57. The introduced VαJα segment was shown to provide chromatin accessibility to Jα segments situated within several kilobases downstream and to suppress germ-line Jα promoter activity and accessibility at greater distances. As a consequence, the VαJα segment directed secondary recombination events to a subset of Jα segments immediately downstream from the primary rearrangement. The data provide the mechanistic basis for a model of primary and secondary T cell receptor α recombination in which recombination events progress in multiple small steps down the Jα array.
Related Links	http://dx.doi.org/10.1073/pnas.0608248104
Starting Page	903
File Format	PDF
ISSN	10916490
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	104
Language	English
Publisher	National Academy of Sciences
Publisher Date	2007-01-16
Access Restriction	Open
Rights Holder	National Academy of Sciences
Subject Keyword	Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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