NDLI: Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin'

Content Provider	PubMed Central
Author	Yamasaki, Satoshi Yagishita, Naoko Sasaki, Takeshi Nakazawa, Minako Kato, Yukihiro Yamadera, Tadayuki Bae, Eunkyung Toriyama, Sayumi Ikeda, Rie Zhang, Lei Fujitani, Kazuko Yoo, Eunkyung Tsuchimochi, Kaneyuki Ohta, Tomohiko Araya, Natsumi Fujita, Hidetoshi Aratani, Satoko Eguchi, Katsumi Komiya, Setsuro Maruyama, Ikuro Higashi, Nobuyo Sato, Mitsuru Senoo, Haruki Ochi, Takahiro Yokoyama, Shigeyuki Amano, Tetsuya Kim, Jaeseob Gay, Steffen Akiyoshi, Fukamizu Nishioka, Kusuki Tanaka, Keiji Nakajima, Toshihiro
Copyright Year	2007
Abstract	Synoviolin, also called HRD1, is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum -associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and pathological processes, including embryogenesis and the pathogenesis of arthropathy. However, little is known about the molecular mechanisms of Synoviolin in these actions. To clarify these issues, we analyzed the profile of protein expression in synoviolin-null cells. Here, we report that Synoviolin targets tumor suppressor gene p53 for ubiquitination. Synoviolin sequestrated and metabolized p53 in the cytoplasm and negatively regulated its cellular level and biological functions, including transcription, cell cycle regulation and apoptosis. Furthermore, these p53 regulatory functions of Synoviolin were irrelevant to other E3 ubiquitin ligases for p53, such as MDM2, Pirh2 and Cop1, which form autoregulatory feedback loops. Our results provide novel insights into p53 signaling mediated by Synoviolin.
Related Links	http://dx.doi.org/10.1038/sj.emboj.7601490
Ending Page	122
Page Count	10
Starting Page	113
File Format	PDF
ISSN	02614189
e-ISSN	14602075
Journal	The EMBO Journal
Issue Number	1
Volume Number	26
Language	English
Publisher	Nature Publishing Group
Publisher Date	2007-01-10
Access Restriction	Open
Rights Holder	Nature Publishing Group
Subject Keyword	Biochemistry, Genetics and Molecular Biology(all) Immunology and Microbiology(all) Neuroscience(all) Molecular Biology Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Neuroscience Immunology and Microbiology Medicine Molecular Biology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

Importance of E3 ubiquitin ligase Synoviolin in fibrogenesis

The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin'

Similar Documents

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

Importance of E3 ubiquitin ligase Synoviolin in fibrogenesis

The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways

SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin'