NDLI: Effect of immune serum and role of individual Fcγ receptors on the intracellular distribution and survival of Salmonella enterica serovar Typhimurium in murine macrophages

Content Provider	PubMed Central
Author	Hazel, Uppington Menager, Nathalie Boross, Peter Wood, James Sheppard, Mark Verbeek, Sjef Mastroeni, Pietro
Copyright Year	2006
Abstract	Immune serum has a protective role against Salmonella infections in mice, domestic animals and humans. In this study, the effect of antibody on the interaction between murine macrophages and S. enterica serovar Typhimurium was examined. Detailed analysis at the single-cell level demonstrated that opsonization of the bacteria with immune serum enhanced bacterial uptake and altered bacterial distribution within individual phagocytic cells. Using gene-targeted mice deficient in individual Fc gamma receptors it was shown that immune serum enhanced bacterial internalization by macrophages via the high-affinity immunoglobulin G (IgG) receptor, Fc gamma receptor I. Exposure of murine macrophages to S. enterica serovar Typhimurium opsonized with immune serum resulted in increased production of superoxide, leading to enhanced antibacterial functions of the infected cells. However, opsonization of bacteria with immune serum did not increase either nitric oxide production in response to S. enterica serovar Typhimurium or fusion of phagosomes with lysosomes.
Related Links	http://dx.doi.org/10.1111/j.1365-2567.2006.02416.x
Ending Page	158
Page Count	12
Starting Page	147
File Format	PDF
ISSN	00192805
e-ISSN	13652567
Journal	Immunology
Issue Number	2
Volume Number	119
Language	English
Publisher	Blackwell Science Inc
Publisher Date	2006-10-01
Access Restriction	Open
Rights Holder	Blackwell Science Inc
Subject Keyword	Immunology Immunology and Allergy Research in Higher Education
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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